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Five Open Problems for the Blockchain Computer | Andreessen Horowitz https://a16z.com/five-open-problems-for-the-blockchain-computer/

Do you sometimes wish you had been born in a different decade so you could have worked on the fundamental building blocks of modern computing? How fun, challenging, and fulfilling would it have been to work on semiconductors in the 1950s or Unix in the 1960s (both at Bell Labs) or personal computers ...

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Are We Ready for the Cure for Cancer? | Andreessen Horowitz https://a16z.com/are-we-ready-for-the-cure-for-cancer/

The entire healthcare system is built around the idea that we can detect, diagnose, and manage disease effectively for patients. This pandemic has been a stress test of that capability, and we have roundly failed that test. If we can’t do those “easy” things—test for the virus, provide ...

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        desc: "Living in silos As software continues to eat the world, we spend an ever-increasing portion of our time online. Worldwide, we pass over 35 billion hours a month in the digital world, with US Internet users spending an average of 32 hours online monthly. As the Web has evolved, more and more of that ...",
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Put the Internet To Work For You | Andreessen Horowitz https://a16z.com/put-the-internet-to-work-for-you/

Living in silos As software continues to eat the world, we spend an ever-increasing portion of our time online. Worldwide, we pass over 35 billion hours a month in the digital world, with US Internet users spending an average of 32 hours online monthly. As the Web has evolved, more and more of that ...

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The Rise of the Exponential Organization | Andreessen Horowitz https://a16z.com/podcast/the-rise-of-the-exponential-organization/

Many companies today are grappling with a few things: an economic downturn, potential layoffs and restructuring, and trying to keep up with the latest tech trends… all while still maintaining a growth trajectory. In this episode, you’ll learn which companies are uniquely designed to weather this ...

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Investing in Gate Bioscience | Andreessen Horowitz https://a16z.com/announcement/investing-in-gate-bio/

While most small molecule drugs bind and inhibit the disease-causing activity of their (typically intracellular) protein targets, Gate Bio instead attacks harmful extracellular proteins by eliminating them at their very root: right where they are produced and secreted from the cell.

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A Practical Toolkit for Deep Learning in the Life Sciences | Andreessen Horowitz https://a16z.com/a-practical-toolkit-for-deep-learning-in-the-life-sciences/

Bharath Ramsundar, Peter Eastman, Pat Walters, and I wrote Deep Learning for the Life Sciences with one primary message in mind: you can easily now do world-class AI in Bio from your laptop. Bringing AI to the life sciences has never been more exciting, or more rewarding — resulting in everything ...

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The 1000x Developer | Andreessen Horowitz https://a16z.com/podcast/the-1000x-developer/

A small minority – likely less than 1% – of the world can code. Yet it is also widely known that the skillset tends to yield outsized returns, with developers generating some of the highest paying salaries out there. But the field is quickly shifting, especially with the advent of wide-scale AI. ...

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Funding When Capital Isn’t Cheap | Andreessen Horowitz https://a16z.com/funding-when-capital-isnt-cheap/

When capital becomes more expensive, how do you evaluate and decide on the best financing option for your company?

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        desc: "This piece was originally published in The Free Press.\u{a0} \u{a0} One of the greatest Saturday Night Live skits in recent memory begins in Philadelphia in 1789. A fife plays as James Madison announces the First Amendment, the cornerstone of our republic: “Congress shall make no law respecting an ...",
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The Right to Bear Technology: America’s Other Second Amendment | Andreessen Horowitz https://a16z.com/the-right-to-bear-technology/

This piece was originally published in The Free Press.    One of the greatest Saturday Night Live skits in recent memory begins in Philadelphia in 1789. A fife plays as James Madison announces the First Amendment, the cornerstone of our republic: “Congress shall make no law respecting an ...

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FlyHomes | Andreessen Horowitz https://a16z.com/announcement/flyhomes/

“You can observe a lot just by watching.” –Yogi Berra David Ricardo was born in the late 18th century, and along with Adam Smith was one of the most influential early economists, pioneering the term “comparative advantage.” A plumber is more productive at plumbing; a locksmith is more ...

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Investing in Upstash | Andreessen Horowitz https://a16z.com/announcement/investing-in-upstash/

Upstash powers caching and messaging for tens of thousands of production applications across four different products, including many AI applications.

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a16z Podcast: Software and Overcoming the Randomness of Birthplace | Andreessen Horowitz https://a16z.com/podcast/a16z-podcast-software-and-overcoming-the-randomness-of-birthplace/

If your income can flow from any place on the globe, and you can earn your money on the Internet, the question for individuals and startup teams alike increasingly is: where do I go? In the tech industry the answer more often than not has been Silicon Valley. For many people and companies that...

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        desc: "A lot is going on in the world of healthcare right now, and one topic that’s especially relevant is how diagnostic labs work. In this episode with Dave King, Executive Chairman of Lab Corp (one of the largest clinical lab networks in the world) and a16z’s General Partner Jorge Conde and Hanne ...",
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Labs for Diagnostics—Then, Now, and Next | Andreessen Horowitz https://a16z.com/podcast/a16z-podcast-labs-for-diagnostics-then-now-and-next/

A lot is going on in the world of healthcare right now, and one topic that’s especially relevant is how diagnostic labs work. In this episode with Dave King, Executive Chairman of Lab Corp (one of the largest clinical lab networks in the world) and a16z’s General Partner Jorge Conde and Hanne ...

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a16z Podcast: Scaling Companies… and Culture | Andreessen Horowitz https://a16z.com/podcast/a16z-podcast-scaling-companies-and-culture/

In this episode of the a16z Podcast sharing more founder stories, Ben Horowitz interviews a16z partner Lars Dalgaard about SuccessFactors, one of the earlier software-as-a-service companies. (It was founded on 2001, IPO’d in 2008, and was acquired by SAP in 2012). SuccessFactors focused on ...

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        desc: "This first appeared in the monthly a16z fintech newsletter.\u{a0}Subscribe to stay on top of the latest fintech news. Fintech’s open source evolution: how banking services will become “easy” to code Until very recently, financial services were notoriously hard and expensive to build. Incumbents ...",
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Making Financial Services Easy to Code (October 2021 Fintech Newsletter) | Andreessen Horowitz https://a16z.com/newsletter/making-financial-services-easy-to-code-october-2021-fintech-newsletter/

This first appeared in the monthly a16z fintech newsletter. Subscribe to stay on top of the latest fintech news. Fintech’s open source evolution: how banking services will become “easy” to code Until very recently, financial services were notoriously hard and expensive to build. Incumbents ...

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Designing a Culture of Reinvention | Andreessen Horowitz https://a16z.com/podcast/a16z-podcast-designing-a-culture-of-reinvention/

Since Netflix started in the late 90s as a DVD-by-mail rental service competing with Blockbuster, it has completely reinvented itself… twice – first, when it went from DVD rental to video streaming platform, and then again when it went from licensing to producing original content. But what does ...

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Disruption at Work: It’s More than just WFH | Andreessen Horowitz https://a16z.com/disruption-at-work-its-more-than-just-wfh/

The following tweetstorm has been lightly copy edited and formatted. It can be seen in its original form here.  Debates over work from home vs hybrid vs HQ are becoming increasingly polarized (duh). It seems either one gets it, or not, with little room to disagree. There’s a reason for this, and ...

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Why Malls Are Getting Mauled | Andreessen Horowitz https://a16z.com/why-malls-are-getting-mauled/

“Online is clearly taking share from brick and mortar…this is likely to continue” –International Council of Shopping Centers America has too many malls. I’ve recently blogged that many traditional brick-and-mortar retailers are being threatened with “economic destruction” by their ...

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Investing in Clubhouse | Andreessen Horowitz https://a16z.com/announcement/investing-in-clubhouse/

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Why China’s Version of Email Marketing Is So Effective | Andreessen Horowitz https://a16z.com/why-chinas-version-of-email-marketing-is-so-effective/

When it comes to ecommerce, last year in China often means this year (or next) in the U.S. Numerous online shopping trends have swept China before landing stateside one or two years later. This is happening now with super apps (e.g., WeChat and DoorDash), meaning platforms that customers initially ...